In addition, when we divided the groups according to whether they had liver metastases, we surprisingly found that the infiltration level of CD103+CD8+ TRMs in CRC tissues appeared to be predictive of whether liver metastases occurred in CRC (when the cut-off value was 2/HPF, the sensitivity and specificity were 0.605 and 0.734, respectively) (Fig. 1J). The gene discussed is ITGAE; the disease is colorectal carcinoma.