Moreover, some studies have found that highly infiltrated CD8+ TRM improves the prognosis of patients with cervical cancer, and that HPV E6/E7 vaccine therapy combined with radiotherapy significantly increases the number of intratumoral CD103+CD8+ TRMs [24].These findings imply a close relationship between TRM and immunotherapy and may explain part of the mechanism of radiotherapy (stereotactic radiotherapy) sensitizing immunotherapy. The gene discussed is ITGAE; the disease is cervical cancer.