In addition, the chemokines Eotaxin-2 (P = 0.046), Eotaxin-1 (P < 0.001), and Fracktaline (P < 0.001), and the cytokine IL-31 (P = 0.046) were positively associated with resistance to CRC CT (Fig. 4A). This evidence concerns the gene IL31 and colorectal carcinoma.