Of the soluble-form receptors included, APRIL (P < 0.0001) and CD30 (P = 0.015) were significantly reduced, in contrast to TNF-RII (P = 0.035) and Tweak (P < 0.0001) which were over-expressed in patients with CRC than in healthy controls (Table 2, Fig. 1D). This evidence concerns the gene TNFSF12 and colorectal carcinoma.