ROC curves confirmed the altered association of these 21 factors with altered risk of CRC, suggesting a potential discriminative potential for CRC detection (AUC > 0.6), with TNF-α, BLC, Eotaxin-1, APRIL, and Tweak having a likely potential clinical utility, as verified by the relatively high (> 0.70) AUC values (Table 2). This evidence concerns the gene TNFSF12 and colorectal carcinoma.