MPPE1 and neoplasm: In the tumor microenvironment (TME), DC plays a crucial role, divided into plasmacytoid DC (pDC) and conventional (cDC) or myeloid DC (myDC), further categorized as CD141 (BDCA-3)+ or cDC1 and CD1c (BDCA-1)+ or cDC2 [5].