INSIG1 and cholestasis: CSA, a well-known inducer of cholestasis (Hulzebos et al. 2004; Sharanek et al. 2015), downregulated gene expression of CYP7A1, CYP27A1, BAAT, HNF4A, and INSIG1, while it upregulated ACAT2 and CCL20 gene expression.