In the largest RCT to date involving 136 participants with type 2 diabetes, use of a fully closed-loop system achieved significantly more time spent between 5.6 and 10.0 mmol/l glucose compared with conventional s.c. insulin therapy (65.8 ± 16.8% vs 41.5 ± 16.9%, p<0.001), without increasing the risk of hypoglycaemia [77]. Here, INS is linked to type 2 diabetes mellitus.