The cGAS-STING pathway has been implicated in several monogenic autoimmune diseases, such as Aicardi–Goutières syndrome (AGS), where defects in AGS-causing genes lead to cytosolic nucleic acid accumulation and activation of cGAS-STING pathway (Yan, 2017; Pokatayev et al., 2016; Giordano et al., 2022). Here, CGAS is linked to autoimmune disease.