Furthermore, aberrant activation of the STING pathway due to its deficient retrograde movement from the Golgi to the ER has been associated with COPA syndrome (Steiner et al., 2022; Mukai et al., 2021; Lepelley et al., 2020; Deng et al., 2020). Here, STING1 is linked to autoimmune interstitial lung disease-arthritis syndrome.