De novo or inherited gain-of-function (GOF) mutations in STING result in STING-associated vasculopathy with onset in infancy (SAVI), a rare autoinflammatory genetic disease characterized by constitutive STING trafficking and signaling independent of ligand binding (Liu et al., 2014; Jeremiah et al., 2014; Fremond et al., 2021). Here, STING1 is linked to vascular disorder.