STING1 and STING-associated vasculopathy with onset in infancy: Given the genetic diagnosis of SAVI disease, we hypothesized that the substitution of a serine for a phenylalanine in position 269 would lead to constitutive STING activation, resulting in the upregulation of inflammation and type I IFN responses, as previously reported for other SAVI-causing mutations (Wang et al., 2021; Fremond et al., 2021; Crow and Stetson, 2022).