On the other hand, six targets produced positive Z-scores (>1.96) that indicated increased infection upon CRISPR targeting: RANBP2-like and GRIP domain containing 2 and 4 (RGPD2 and RGPD4), trinucleotide repeat containing adaptor 6B (TNRC6B), FAM21C, KIA00196 (aka, strumpellin), and zyxin. The gene discussed is ZYX; the disease is infection.