HRH1 and hepatitis C virus infection: Through cell-basedquantitative HTS of an approved drug library, He et al. (59) showed that the HRH1 antagonist chlorcyclizine HClinhibited hepatitis C virus infection by targeting the late stage of viral entry.After screening an FDA-approved drug library, another group reported that twoantihistamine drugs, carbinoxamine maleate and S-(+)-chlorpheniramine maleate,inhibited a broad spectrum of influenza A virus infections (60).