The results showed that the overexpression of HRH1 inHEK293T cells also significantly enhanced the infection of several pseudotypedSARS-CoV-2 mutants, including D614G, Delta, BA.1, BA.2, BA.2.12.1, and BA.4,demonstrating the universal utilization of HRH1 for SARS-CoV-2 infection (Fig.S3C). This evidence concerns the gene HRH1 and COVID-19.