In the multivariate regression model containing the statistical significantly variables, we found that presence of SO (HR 13.529, 95% CI 7.064–25.912, p = 0.000), was risk factor for OS, tumor stage III was associated with a 4.894‐fold increase overall risk of death compared to patients with tumor staged I (HR 4.849, 95% CI 1.850–12.709, p = 0.027), Alb (HR 0.899, 95% CI 0.815–0.991, p = 0.032) was protective factors for OS (Table 4). The gene discussed is ALB; the disease is neoplasm.