Our previous studies have demonstrated that SRC‐1 acts as a coactivator to promote CRC progression through enhancing GLI2‐mediated Hedgehog signaling.[16] Besides, SRC‐1 also promoted human hepatocellular carcinoma (HCC) progression by activating Wnt/β‐catenin signaling.[23] However, the exact role of tumor cell‐expressed SRC‐1 in tumor immune escape has not been reported yet. This evidence concerns the gene GLI2 and hepatocellular carcinoma.