To further explore the mechanism of SRC‐1 up‐regulation, we treated CRC cells with different concentrations of IFNγ and TNFα, and found that high concentrations of IFNγ (500 ng mL−1) and TNFα (40 ng mL−1) could up‐regulate the expression of SRC‐1 (Figure S9, Supporting Information), indicating that αPD‐L1 treatment may induce SRC‐1 expression by promoting the production of different cytokines such as IFNγ and TNFα in the TME. Here, TNF is linked to colorectal carcinoma.