revealed that SPOP inhibited the immune escape of cancer cells by degrading PD‐L1 in prostate cancer.[32] In this study, we demonstrated that SRC‐1 could interact with SPOP but could not be degraded by SPOP, suggesting that SRC‐1 executes a sponge‐like function to absorb SPOP, leading to reduce the chances of the interaction between SPOP and PD‐L1, and consequently stabilize PD‐L1. This evidence concerns the gene SRC and Familial prostate cancer.