Knockdown of SOCS1 in wild‐type CMT93 cells up‐regulated the phosphorylation of JAK1 and STAT3 as well as protein and mRNA levels of IRF1 and PD‐L1 (Figure S2E,F, Supporting Information), and knockdown of SOCS1 in KOSRC‐1 CMT93 cells partially restored p‐JAK1 and p‐STAT3 protein levels as well as IRF1 and PD‐L1 expression (Figure 3F), demonstrating that up‐regulation of SOCS1 in KOSRC‐1 CRC cells contributes to the suppression of JAK1‐STAT3 signaling. Here, SOCS1 is linked to colorectal carcinoma.