SRC‐1 promotes CRC immune escape by enhancing PD‐L1 expression via multiple mechanisms: SRC‐1 enhances HDAC8 expression to inhibit SOCS1 expression, leading to JAK1‐STAT3 signaling pathway activation and PD‐L1 up‐regulation; SRC‐1 coactivates STAT3 and IRF1 to enhance PD‐L1 transcription; SRC‐1 stabilizes PD‐L1 protein by preventing SPOP binding to PD‐L1 for ubiquitination and degradation. This evidence concerns the gene SPOP and colorectal carcinoma.