It has been reported that histone deacetylase 8 (HDAC8) can inhibit SOCS1 expression,[29] and our RNA‐seq data showed HDAC8 expression was down‐regulated in KOSRC‐1 CRC cells (Figure 3A), which was confirmed by RT‐qPCR and Western blot analysis (Figure 3G). Here, HDAC8 is linked to colorectal carcinoma.