Increased IL‐6 was found in CPT‐11 and SCR/SN38‐NP groups, associated with chemotherapy resistance and immune suppression.[30] In contrast, anti‐tumor immunomodulators (TNF‐α, IFN‐γ, Gzms‐B, and IL‐2) raised in si/SN38‐NP group, signifying immune activation. This evidence concerns the gene TNF and neoplasm.