ADAM10 and colorectal carcinoma: The impact of ANO family members on A Disintegrin and Metalloproteinases (ADAMs) sheddase activity has been proved.[23] ADAM10 and 17 could shed numerous membrane‐bound proteins, releasing their ectodomains.[24] Following chemotherapy with CPT‐11, ADAM10 was up‐regulated in CRC cells inoculated on CAFs‐derived ECM, accompanied with an increase in its active form (Figure 3F).