We hypothesized that TRPM2 on lysosome could be involved in LP-induced inflammasome since TRPM2 has been reported to be expressed on lysosome as well (Sumoza-Toledo and Penner, 2011) and Trpm2-KO mice are resistant to diet-induced glucose intolerance (Zhang et al., 2012). Here, TRPM2 is linked to Glucose intolerance.