Inflammasome activation was also significantly reduced in WAT of Trpm2-KO mice on HFD as evidenced by the significantly reduced numbers of ASC specks and capase-1 cleavage (Figure 3D and E, Figure 3—source data 1 and 2), indicating that TRPM2 is important in inflammasome related to metabolic syndrome. Here, TRPM2 is linked to metabolic syndrome.