CXCL2 and contact dermatitis: In a study that used a mouse model of contact dermatitis, dietary linseed oil intake suppressed epidermal thickening, and 12-hydroxyeicosapentaenoic acid (12-HEPE), a metabolite of linseed oil and EPA, suppressed the expression of genes encoding pre-inflammatory chemokines (Cxcl1 and Cxcl2) via retinoid X receptors (Rxrα) expressed on keratinocytes in the epidermis, thereby reducing skin inflammation [14].