Of note, the stromal accumulation of Gal-1 exhibited a significantly progressive upregulation, transitioning from low to intermediate grades (p < 0.05 for low vs. intermediate-grade PCa) and further escalating in high-grade PCa (p < 0.001 for intermediate- vs. high-grade PCa) (Figure 1B). The gene discussed is LGALS1; the disease is posterior cortical atrophy.