To our knowledge, this study shows for the first time that SAA and ESR are elevated in HAE-C1INH and in HAE-FXII attacks and D-dimer is elevated also in HAE-FXII attacks, since the elevation in AE attacks in patients with C1INH deficiency has been previously described. Here, SAA1 is linked to hyperinsulinemic hypoglycemia, familial, 4.