During acute attacks, SAA was elevated in 88% of the patients (12 HAE-C1INH and 3 HAE-FXII) with a median of 16.8 mg/dL (IQR 9.9–23.7); ESR in 65% (7 HAE-C1INH and 4 HAE-FXII), median 44 mm/h (IQR 28–62); and D-dimer was increased in 71% (9 HAE-C1INH and 3 HAE-FXII), median 938 mg/mL (IQR 417-2930). This evidence concerns the gene SAA1 and hereditary angioedema.