The translocation of Xp11.2 RCC is distinguished by a gene fusion between TFE3 and several other genes, including ASPL (17q25), CLTC (17q23), NonO (Xp12), PSF (1q34), and PRCC (1q21), along with the translocation on chromosome Xp11.2 [11]. The gene discussed is ASPSCR1; the disease is renal cell carcinoma.