IGFBPs and IGF play pivotal roles in the IGF signaling pathway, exerting significant impacts on tumor initiation, progression, metastasis, and chemoresistance (Han & Kim, 2021; Lee, Tocheny & Shaw, 2022; Lee et al., 2022; Du et al., 2017; Martinez Baez et al., 2023) that lead to antitumor effects (Cai, Dozmorov & Oh, 2020). This evidence concerns the gene IGF1 and neoplasm.