Age (hazard ratio (HR): 3.400, 95% CI [1.865–6.198], p < 0.001), differentiation grade (HR: 2.767, 95% CI [1.627–4.704], p < 0.001), tumor size (HR: 1.921, 95% CI [1.117–3.304], p = 0.018), TNM stage (HR: 1.867, 95% CI [1.332–2.617], p < 0.001), CEA level (HR: 2.967, 95% CI [1.664–5.290], p < 0.001), and CKMT2 level (HR: 2.925, 95% CI [1.686–5.076], p < 0.001) were found to be associated with the prognosis of patients with CRC (Table 2). The gene discussed is CKMT2; the disease is colorectal carcinoma.