The loss of function of certain PTPs, such as PTPN13 (Mcheik et al., 2020), PTEN (González-García et al., 2022), PTPRD (Szaumkessel et al., 2017), and the receptor protein tyrosine phosphatases γ (RPTPγ or PTPRG) and ζ (RPTPζ or PTPRZ), can contribute to cancer progression (Boni and Sorio, 2021; Sloth et al., 2022). Here, PTPRG is linked to cancer.