Through the analysis of the correlation between core genes and signaling pathways, it was observed that high-frequency genes such as TGFβ1 and TNF, relevant to macrophages and PF, are primarily associated with pathways such as cytokine–cytokine receptor interaction, AGE-RAGE signaling pathway in diabetic complications, and Lipid and atherosclerosis. This evidence concerns the gene RENBP and atherosclerosis.