Recent case-controlled studies have suggested that susceptibility to prion diseases is associated with PRND polymorphisms at codon 174 and 3′ untranslated region (UTR) +28 in humans (12, 26, 27), codons 95 and 132 in cattle (28), codon 26 in sheep (29), and codon 10 in goats (54). This evidence concerns the gene PRND and prion disease.