Angiotensin II (Ang II) plays a role in inflammation and endothelial dysfunction by initiating an inflammatory cascade and reactive oxygen species (ROS) production (Dinh et al., 2014 ▶; Ku et al., 2019 ▶; Pugh et al., 2019 ▶; Xu et al., 2022 ▶), which contribute to inflammatory processes and CKD progression. The gene discussed is AGT; the disease is endothelial dysfunction.