Several anti-inflammatory and antioxidant proteins, such as alpha-1-microglobulin and α1-acid glycoprotein, as well as inflammatory markers including complement factor D, β-trace protein, β-2-microglobulin, retinol-binding protein 4, and cystatin-C, are implicated in both CKD and hypertension (Aleksenko et al., 2020 ▶; Argyropoulos et al., 2017 ▶; Farjo et al., 2012 ▶; McCullough et al., 2014 ▶; Okura et al., 2010 ▶; White, Ghazan-Shahi, and Adams, 2015 ▶). The gene discussed is CST3; the disease is chronic kidney disease.