Pharmacological approaches for managing hypertension in CKD patients include angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers (ARBs), and diuretics, either prescribed individually or in combination based on eGFR (Hamrahian and Falkner, 2017 ▶; Pugh et al., 2019 ▶). This evidence concerns the gene ACE and chronic kidney disease.