On the other hand, the protected groups showed significant increases in body weight, and decreases in HWI and cardiac enzymes, and the extracts effectively prevented disruptions in antioxidant enzyme activities and lipids, increased cardiac Nrf2 and CBR1 expressions and SOD activity, but the MDA and NO levels were decreased, indicating that the extracts prevented heart hypertrophy and damage, enhanced cardiac functions, and reduced the oxidative damage (Zhang et al., 2021 ▶). Here, SOD1 is linked to cardiac hypertrophy.