Also, by examining the effects of an apigenin -enriched diet in a Dextran sulfate sodium (DSS) -induced chronic colitis model in rodents, it was shown that apigenin supplementation reduces the symptoms of colitis damage as well as IL-1b and TNF-a levels (Marquez-Flores et al., 2016 ▶). The gene discussed is IL1B; the disease is colitis.