It is also claimed that the inflammatory response to LPS exposure in airway epithelial cells and macrophages is mainly caused by the increase of IL-6, and TNF-a (Liu et al., 2016 ▶).  Sepsis has been shown to increase serum IL-6, and one of the ways to induce experimental sepsis is to administer LPS. The gene discussed is TNF; the disease is Sepsis.