Furthermore, systematic administration of curcumin (30 and 100 mg/kg) can result in the suppression of gene expression of PGE2, IL-6, and TNF-α and significant and dose-dependent inhibition of NF-kB activation in periodontitis in vivo (Guimarães et al., 2011 ▶). Here, NFKB1 is linked to periodontitis.