Recently, the anti-inflammatory impacts of curcumin on the disease have been demonstrated by Justo et al. They revealed these effects through curcumin administration (once a day for 15 days, orally) in an animal model of apical periodontitis by reducing the levels of pro-inflammatory agents including IL-1β, TNF-α, and IL-6 (Justo et al., 2022 ▶). This evidence concerns the gene TNF and periapical periodontitis.