NLRP3 and intervertebral disk degenerative disorder: During the progression of IDD, the gradually increasing activation of the NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome elicits the cleavage of caspase-1 and secretion of interleukin (IL)-1β, which results in cell rupture and damage to the surrounding ECM [14].