[39] found that miR-148a from M2-sEVs attenuated myocardial ischemia/reperfusion injury by down-regulating the expression of TXNIP protein and inhibiting the toll-like receptor-4 (TLR4)/NF-κB/NLRP3 pyroptosis signaling axis. Here, TLR4 is linked to myocardial ischemia.