CFTR and Airway obstruction: Mutations in the CFTR gene encode a nonfunctional chloride channel, causing a broad range of deleterious effects (Ramananda et al., 2024) including obstructive lung disease and increased susceptibility to respiratory infections (Rowntree and Harris, 2003), pancreatic disorders (Estivill et al., 1995), and reduced fertility in both males (Alves et al., 2015) and females (Brunoro et al., 2011).