Nicotinamide-N-methyltransferase also promotes remethylation of homocysteine to S-adenosylmethionine (another pathwayfor homocysteine utilization) (Hong et al., 2018), positivelycorrelates with obesity and insulin resistance (Kannt et al.,2015), and presumably regulates the expression of fructose-1,6-bisphosphataseinvolved in the process of gluconeogenesis(Visinoni et al., 2008). This evidence concerns the gene NNMT and obesity due to melanocortin 4 receptor deficiency.