Initially, genes associatedwith clubfoot (PITX1, TBX4, HOXA9, HOXD10, HOXD12,HOXD13, HOXA9, TPM1, TPM2, COL9A1, FLNB, CASP8,CASP10, UTX, CHD1, RIPPLY2, CAND2, WNT7) werescreened for potential variants. The gene discussed is TBX4; the disease is clubfoot.