Initially, genes associatedwith clubfoot (PITX1, TBX4, HOXA9, HOXD10, HOXD12,HOXD13, HOXA9, TPM1, TPM2, COL9A1, FLNB, CASP8,CASP10, UTX, CHD1, RIPPLY2, CAND2, WNT7) werescreened for potential variants. This evidence concerns the gene HOXD10 and familial clubfoot with or without associated lower limb anomalies.