The representative images were shown in Figures 6A, C, with a dose-dependent downregulation of phosphorylated PI3K (p-PI3K), phosphorylated AKT (p-AKT), and ERK (p-ERK) in both 4T1 and HCC-1806 cells following exposure to 40 and 80 μg/mL CLENs (Figures 6B, D). The gene discussed is AKT1; the disease is hepatocellular carcinoma.