ADA, adalimumab; SC, subcutaneously; ASAS, ASsessment in AS; AS, ankylosing spondylitis; BASDAI, Bath AS Disease Activity Index; CRP, C-reactive protein; BASMI, Bath AS Metrology Index; SF-36 PCS, Short Form-36 physical component summary score; ASQoL, Ankylosing Spondylitis Quality of Life Questionnaire; BASFI, Bath AS Functional Index; MMP-3, serum metalloproteinase 3; CTX-II, urinary type II collagen C-telopeptides; NTX, serum type I collagen N-telopeptides. The gene discussed is CRP; the disease is ankylosing spondylitis.