The total amino acid homology of the WNT8A and WNT8B genes was 60.0%, and human WNT8A mRNA was expressed in NT2 cells with neural differentiation potential, whereas human WNT8B mRNA was expressed in diffuse gastric cancer (34).WNT8B was significantly up-regulated in gastric cancer cell lines.WNT8B may play a critical role in gastric cancer by activating the β-catenin-TCF signaling pathway (35). The gene discussed is HNF4A; the disease is gastric cancer.