Moreover, knockdown of FZD7 decreased the expression of the stem cell genes Nanog and Oct-4, the multidrug resistance transporter protein gene ABCG2, and the tumor stem cell-associated surface antigens CD133, CD44, and CD24, indicating that FZD7 possibly involved in the regulation of gastric cancer stem cell function and drug resistance (46). The gene discussed is NANOG; the disease is gastric cancer.