Collagen type X alpha 1 (COL10A1) activates the WNT2-mediated Wnt pathway and promotes the development of gastric cancer (15), and the vast majority of patients with high expression of WNT2 have cancer in TNM Stage III or IV with lymph node metastasis, it may be a marker for patients with advanced GC (14). This evidence concerns the gene COL10A1 and gastric cancer.