TGFB1 and neoplasm: Within the context of human malignancies, six distinct types of immune infiltration which were defined as the relative abundance of a set of immune cell populations, ranging from tumor promoting to tumor inhibiting, namely C1 (wound healing), C2 (INF-r dominant), C3 (inflammatory), C4 (lymphocyte depleted), C5 (immunologically quiet), and C6 (TGFβ dominant) (18).