Ovarian cancers with BRCA1 alterations (germline and somatic mutations in 12% of cases, DNA hypermethylation in 11% of cases) and BRCA2 alterations (germline and somatic mutations in 11% of cases) (7), are associated with homologous recombination deficiency (HRD). The gene discussed is BRCA2; the disease is ovarian carcinoma.