Moreover, herbal formulations, namely Shengmusan, Xinkeshu, and Qiliqiangxin capsule, could aid in enhancing endothelial functionality in pathologies like blood-brain barrier dysfunction and coronary artery disease, as well as in the mediatory role of Piezo1 channels in reducing blood-brain barrier permeability, thereby improving cardiovascular disease conditions (107, 108). This evidence concerns the gene PIEZO1 and cardiovascular disorder.