There are differences in the literature on hepatitis-B immunity status and vaccinations.5-7 In terms of immunization, extensive and detailed studies are needed due to vaccine procedures, administered doses, time differences, and application inadequacies.8-10 In this study, we aimed to examine the relationship between Hepatitis B vaccination status and demographic and hepatitis B marker indicators of individuals receiving health care in family medicine between 2010 and 2022. The gene discussed is PPIB; the disease is Hepatitis.