In this study, methods such as MSP, immunohistochemistry and real-time fluorescence PCR were employed to analyze the methylation status, protein and nucleic acid expression of NRG in different pathological stages of cervical carcinoma, and a correlation analysis was conducted between NRG1 expression in cervical carcinoma and the clinical characteristics of patients with cervical carcinoma, patients endocervical neoplasia and normal population. The gene discussed is NRG1; the disease is cervical carcinoma.