SLC47A1 and type 2 diabetes mellitus: However, only one prior study conducted in Pakistani population has highlighted the effect of this transporter gene on responder and non-responder ratio in our region.11 Thus, the main objective of our study was to explore the genotypic and allelic frequencies of SNP rs77630697 on SLC47A1 and to investigate the relationship between this genetic variant and metformin efficacy among T2DM patients on metformin monotherapy.