MECP2 and congestive heart failure: MeCP2, a reader of DNA methylation and a component of a co-repressor complex, has been shown to regulate gene expression in chronic heart failure (90) and to attenuate in vitro hypoxia/reperfusion-induced injury in H9c2 cardiomyocytes by modulating the SFRP4/Wnt/β-catenin axis (91).