Concerning genetic alterations, genome-wide association studies (GWAS) unveiled numerous genetic risk factors associated with AD, such as APOE4 and TREM2 (R47H), inspiring the development of models aimed to better depict the genetic predisposition for AD in vitro, often obtained through genetic engineering (McQuade and Blurton-Jones, 2019; Claes et al., 2021). Here, APOE is linked to Alzheimer disease.