It has also been found that PDGF can be degraded in alveolar macrophages by regnase-1 to alleviate the progression of PAH, demonstrating the critical role of PDGF in PAH, and the use of chlordiazepoxide and the overexpression of regnase-1 have been recognized as potential therapeutic approaches for the treatment of PAH (25). This evidence concerns the gene ZC3H12A and pulmonary arterial hypertension.