SREBF1 and glomerulosclerosis: Studies have reported that the decreased expression level of fatty acid oxidation regulatory enzyme in renal tubular epithelial cells of diabetic patients contributes to intracellular lipid accumulation and the development of renal fibrosis[43], and the overexpression of SREBP1 in the renal tissues of diabetic mice leads to renal lipid accumulation, renal tubular interstitial fibrosis and glomerulosclerosis[42].