CALCA and demyelinating disease: Our method promotes successful SC differentiation of KC‐NC like stem cells in two weeks without genetic manipulation[51] or laborious and time consuming 3D organoid cultures.[52] Collectively, our data suggests that immobilized growth/differentiation factors enhance NC differentiation and functionality and may be more broadly applicable to other cell types, e.g., oligodendrocytes, melanocytes, SMC, providing a platform for drug testing and cell therapy for demyelinating diseases.