Subsequent studies revealed that METTL3 could not regulate the expression of YTHDC1/YTHDF2 proteins in melanoma, which also predicts that the methylation modifications regulated by METTL3 are not required for all genes, but that METTL3‐mediated m6A‐methylation modification is dependent on DHPS. The gene discussed is YTHDC1; the disease is melanoma.