Meanwhile, the results of the cellular multifactor assays showed that both GL‐1 and GC‐7 inhibited the expression of ANG, PAI‐1, TSP‐1, PDGF, VEGF, FGF2, IGFBP‐3, CSF2, CD71, CXCL1, and MMP9; This also suggests that the inhibition of DHPS activity could effectively inhibit the angiogenesis process of melanoma, which provides a new reference for the indication of DHPS inhibitors. Here, IGFBP3 is linked to melanoma.