Additionally, natural killer (NK) cells possess the ability to lyse cells with reduced major histocompatibility complex (MHC) protein expression, including cancer cells that have undergone mutations.[40] Immune cold tumors, often referred to as non‐inflamed tumors, are characterized by the absence of tumor cells expressing PD‐L1 and CTLs expressing PD‐1. Here, CD274 is linked to neoplasm.