Notably, immune cold tumors exhibit elevated levels of myeloid‐derived stromal cells (MDSCs), M2 macrophages, Tregs, and Th17 cells.[42, 43] Among these components, M2‐polarized macrophages and Tregs play pivotal roles in promoting angiogenesis by releasing adrenomedullin and vascular endothelial growth factors (VEGFs).[44] Additionally, immunosuppressive components such as interleukin‐10 (IL‐10), PD‐L1, and transforming growth factor‐β (TGF‐β) were overexpressed, which contribute to a favorable environment for tumor growth. The gene discussed is CD274; the disease is neoplasm.