Remarkably, in the tumor tissues of mice implanted with LLC‐shPRPS2 cells, we observed a significant increase in the percentage of CD4+ T cells (Figure 4a) and CD8+ T cells (Figure 4b), along with a notable reduction in the percentage of TAM (Figure 4c), M‐MDSC (Figure 4d), and PMN‐MDSC (Figure 4e). This evidence concerns the gene CD4 and neoplasm.