We collected bone marrow specimen and imaging data of 16 newly diagnosed patients with multiple myeloma, and found that the higher the expression level of LILRB4, the more serious the bone lesion (Fig. 1D and Supplementary Fig. S2D), suggesting that there was a certain trend and LILRB4 may be involved in bone injury in multiple myeloma. The gene discussed is LILRB4; the disease is plasma cell myeloma.