Through mIF and IHC techniques applied to the Renji TMA cohort, we were able to identify the presence of PLOD2 + SAA1 + ccRCC cells and we found this tumor subclusters were related with high infiltration of CD163 + macrophages and Treg cells, indicating the establishment of an immunosuppressed TME. This evidence concerns the gene PLOD2 and nonpapillary renal cell carcinoma.