In addition, Yang et al. [56] showed that the miR-203 may function as a cardioprotective regulator in DCM, as its up-regulation could reduce myocardial hypertrophy, myocardial fibrosis, myocardial apoptosis by targeting PIK3CA via inactivation of PI3K/Akt signaling pathway. This evidence concerns the gene PIK3CA and familial dilated cardiomyopathy.