Che et al. showed that melatonin administration significantly ameliorated cardiac dysfunction and reduced collagen production via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3 inflammasome and TGF-β1/Smads signaling pathway, while the expression of TGF-β1, p-Smad2, p-Smad3, NLRP3, ASC, cleaved caspase-1, mature IL-1β, and IL-18 were downregulated in the heart of mice with diabetes mellitus following melatonin treatment [116]. This evidence concerns the gene TGFB1 and diabetes mellitus.