WEE1 and central nervous system cancer: Ma et al. revealed that LINC00470 was up-regulated in serum sEVs from glioma patients and correlated with disease progression and postoperative survival of glioma patients, and sEVs-LINC00470 in GBM can bind to miR-580-3p in glioma cells to regulate WEE1 expression and activate the PI3K/AKT/mTOR pathway, thereby enhancing the proliferation of glioma cells [76].