Immunoglobulin κ J region recombinant signal binding protein (RBP-J) is a transcriptional regulator indicating that sEVs-circBTG2 secreted by RBP-J overexpressed macrophages inhibits the proliferation and invasion of glioma cells through the circBTG2/miR-25-3p/PTEN pathway [82]. Here, RBPJ is linked to central nervous system cancer.